Whole exome sequencing approach to childhood onset familial erythrodermic psoriasis unravels a novel mutation of CARD14 requiring unusual high doses of ustekinumab

• Main Authors: S. Signa (Author), E. Campione (Author), M. Rusmini (Author), S. Chiesa (Author), A. Grossi (Author), A. Omenetti (Author), R. Caorsi (Author), G. M. Viglizzo (Author), M. Galluzzo (Author), L. Bianchi (Author), M. Talamonti (Author), A. Orlandi (Author), A. Martini (Author), I. Ceccherini (Author), M. Gattorno (Author)
• Format: Book
• Published: BMC, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Autosomal dominant gain of function mutations in caspase recruitment domain family member 14 (CARD14) is a rare condition associated with plaque-type psoriasis, generalized pustular psoriasis, palmoplantar pustular psoriasis and pityriasis rubra pilaris. Recently, a new CARD14 -a...