Applicability of free drug hypothesis to drugs with good membrane permeability that are not efflux transporter substrates: A microdialysis study in rats

• প্রধান লেখক: Chun Chen (লেখক), Hongyu Zhou (লেখক), Chi Guan (লেখক), Huanhuan Zhang (লেখক), Yingying Li (লেখক), Xue Jiang (লেখক), Zheng Dong (লেখক), Yuanyuan Tao (লেখক), Juan Du (লেখক), Shuyao Wang (লেখক), Teng Zhang (লেখক), Na Du (লেখক), Junyang Guo (লেখক), Yaqiong Wu (লেখক), Zehai Song (লেখক), Haofei Luan (লেখক), Yu Wang (লেখক), Hongwen Du (লেখক), Shaofeng Zhang (লেখক), Chen Li (লেখক), Hang Chang (লেখক), Tao Wang (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Wiley, 2020-04-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Abstract In clinical pharmacology, the free drug hypothesis has been widely applied in the interpretation of the relationship between pharmacokinetics and pharmacodynamics (PK/PD). The free drug hypothesis assumes that the unbound drug concentration in blood is the same as that in the site of action...