Applicability of free drug hypothesis to drugs with good membrane permeability that are not efflux transporter substrates: A microdialysis study in rats

• Main Authors: Chun Chen (Author), Hongyu Zhou (Author), Chi Guan (Author), Huanhuan Zhang (Author), Yingying Li (Author), Xue Jiang (Author), Zheng Dong (Author), Yuanyuan Tao (Author), Juan Du (Author), Shuyao Wang (Author), Teng Zhang (Author), Na Du (Author), Junyang Guo (Author), Yaqiong Wu (Author), Zehai Song (Author), Haofei Luan (Author), Yu Wang (Author), Hongwen Du (Author), Shaofeng Zhang (Author), Chen Li (Author), Hang Chang (Author), Tao Wang (Author)
• Format: Book
• Published: Wiley, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract In clinical pharmacology, the free drug hypothesis has been widely applied in the interpretation of the relationship between pharmacokinetics and pharmacodynamics (PK/PD). The free drug hypothesis assumes that the unbound drug concentration in blood is the same as that in the site of action...