Prevalence of inversions in introns 1 and 22 of the factor VIII gene and inhibitors in patients from southern Brazil

• Egile Nagusiak: Maria Cristina S. M. Corrêa (Egilea), Euripides Ferreira (Egilea), Marcelo T. A. Veiga (Egilea), Eliane Bandinelli (Egilea), Clévia Rosset (Egilea)
• Formatua: Liburua
• Argitaratua: Sociedade Brasileira de Patologia Clínica.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

ABSTRACT Objectives: The development of antibodies (inhibitors) against exogenous factors is the main complication in the treatment of hemophilia. Both genetic and non-genetic factors are related to inhibitor development. Among the genetic factors, the type of mutation that caused the disease is one...