Challenging inflammatory process at molecular, cellular and in vivo levels via some new pyrazolyl thiazolones

• Main Authors: Perihan A. Elzahhar (Author), Rana A. Alaaeddine (Author), Rasha Nassra (Author), Azza Ismail (Author), Hala F. Labib (Author), Mohamed G. Temraz (Author), Ahmed S. F. Belal (Author), Ahmed F. El-Yazbi (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The work reported herein describes the synthesis of a new series of anti-inflammatory pyrazolyl thiazolones. In addition to COX-2/15-LOX inhibition, these hybrids exerted their anti-inflammatory actions through novel mechanisms. The most active compounds possessed COX-2 inhibitory activities compara...