Challenging inflammatory process at molecular, cellular and in vivo levels via some new pyrazolyl thiazolones

• Auteurs principaux: Perihan A. Elzahhar (Auteur), Rana A. Alaaeddine (Auteur), Rasha Nassra (Auteur), Azza Ismail (Auteur), Hala F. Labib (Auteur), Mohamed G. Temraz (Auteur), Ahmed S. F. Belal (Auteur), Ahmed F. El-Yazbi (Auteur)
• Format: Livre
• Publié: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

The work reported herein describes the synthesis of a new series of anti-inflammatory pyrazolyl thiazolones. In addition to COX-2/15-LOX inhibition, these hybrids exerted their anti-inflammatory actions through novel mechanisms. The most active compounds possessed COX-2 inhibitory activities compara...