Challenging inflammatory process at molecular, cellular and in vivo levels via some new pyrazolyl thiazolones

• Главные авторы: Perihan A. Elzahhar (Автор), Rana A. Alaaeddine (Автор), Rasha Nassra (Автор), Azza Ismail (Автор), Hala F. Labib (Автор), Mohamed G. Temraz (Автор), Ahmed S. F. Belal (Автор), Ahmed F. El-Yazbi (Автор)
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• Опубликовано: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Предметы: article
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The work reported herein describes the synthesis of a new series of anti-inflammatory pyrazolyl thiazolones. In addition to COX-2/15-LOX inhibition, these hybrids exerted their anti-inflammatory actions through novel mechanisms. The most active compounds possessed COX-2 inhibitory activities compara...