The impact of nucleoside base modification in mRNA vaccine is influenced by the chemistry of its lipid nanoparticle delivery system

• मुख्य लेखकों: Marie-Clotilde Bernard (लेखक), Emilie Bazin (लेखक), Nadine Petiot (लेखक), Katia Lemdani (लेखक), Sylvie Commandeur (लेखक), Cécile Verdelet (लेखक), Sylvie Margot (लेखक), Vladimir Perkov (लेखक), Manon Ripoll (लेखक), Marie Garinot (लेखक), Sophie Ruiz (लेखक), Florence Boudet (लेखक), Bachra Rokbi (लेखक), Jean Haensler (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2023-06-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The use of modified nucleosides is an important approach to mitigate the intrinsic immunostimulatory activity of exogenous mRNA and to increase its translation for mRNA therapeutic applications. However, for vaccine applications, the intrinsic immunostimulatory nature of unmodified mRNA could help i...