The impact of nucleoside base modification in mRNA vaccine is influenced by the chemistry of its lipid nanoparticle delivery system

• প্রধান লেখক: Marie-Clotilde Bernard (লেখক), Emilie Bazin (লেখক), Nadine Petiot (লেখক), Katia Lemdani (লেখক), Sylvie Commandeur (লেখক), Cécile Verdelet (লেখক), Sylvie Margot (লেখক), Vladimir Perkov (লেখক), Manon Ripoll (লেখক), Marie Garinot (লেখক), Sophie Ruiz (লেখক), Florence Boudet (লেখক), Bachra Rokbi (লেখক), Jean Haensler (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2023-06-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

The use of modified nucleosides is an important approach to mitigate the intrinsic immunostimulatory activity of exogenous mRNA and to increase its translation for mRNA therapeutic applications. However, for vaccine applications, the intrinsic immunostimulatory nature of unmodified mRNA could help i...