The impact of nucleoside base modification in mRNA vaccine is influenced by the chemistry of its lipid nanoparticle delivery system

• Main Authors: Marie-Clotilde Bernard (Author), Emilie Bazin (Author), Nadine Petiot (Author), Katia Lemdani (Author), Sylvie Commandeur (Author), Cécile Verdelet (Author), Sylvie Margot (Author), Vladimir Perkov (Author), Manon Ripoll (Author), Marie Garinot (Author), Sophie Ruiz (Author), Florence Boudet (Author), Bachra Rokbi (Author), Jean Haensler (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The use of modified nucleosides is an important approach to mitigate the intrinsic immunostimulatory activity of exogenous mRNA and to increase its translation for mRNA therapeutic applications. However, for vaccine applications, the intrinsic immunostimulatory nature of unmodified mRNA could help i...