Opportunities for Successful Stabilization of Poor Glass-Forming Drugs: A Stability-Based Comparison of Mesoporous Silica Versus Hot Melt Extrusion Technologies

• Principais autores: Felix Ditzinger (Autor), Daniel J. Price (Autor), Anita Nair (Autor), Johanna Becker-Baldus (Autor), Clemens Glaubitz (Autor), Jennifer B. Dressman (Autor), Christoph Saal (Autor), Martin Kuentz (Autor)
• Formato: Livro
• Publicado em: MDPI AG, 2019-11-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Amorphous formulation technologies to improve oral absorption of poorly soluble active pharmaceutical ingredients (APIs) have become increasingly prevalent. Currently, polymer-based amorphous formulations manufactured by spray drying, hot melt extrusion (HME), or co-precipitation are most common. Ho...