Synthesis of Pyrrolo[3,4-<i>b</i>]pyridin-5-ones via Ugi-Zhu Reaction and In Vitro-In Silico Studies against Breast Carcinoma

• Main Authors: Ivette Morales-Salazar (Author), Carlos E. Garduño-Albino (Author), Flora P. Montes-Enríquez (Author), Dania A. Nava-Tapia (Author), Napoleón Navarro-Tito (Author), Leonardo David Herrera-Zúñiga (Author), Eduardo González-Zamora (Author), Alejandro Islas-Jácome (Author)
• Format: Book
• Published: MDPI AG, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

An Ugi-Zhu three-component reaction (UZ-3CR) coupled in a one-pot manner to a cascade process (<i>N</i>-acylation/<i>aza</i> Diels-Alder cycloaddition/decarboxylation/dehydration) was performed to synthesize a series of pyrrolo[3,4-<i>b</i>]pyridin-5-ones in 20% t...