Phosphatase-independent functions of SHP2 and its regulation by small molecule compounds

• मुख्य लेखकों: Wenjie Guo (लेखक), Qiang Xu (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2020-11-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

SHP2 is a non-receptor protein tyrosine phosphatase encoded by the PTPN11 gene in human. Clinically, SHP2 has been identified as a causal factor of several diseases, such as Noonan syndrome, LEOPARD syndrome as well as myeloid malignancies. Interestingly, both loss-of-function and gain-of-function m...