Phosphatase-independent functions of SHP2 and its regulation by small molecule compounds

SHP2 is a non-receptor protein tyrosine phosphatase encoded by the PTPN11 gene in human. Clinically, SHP2 has been identified as a causal factor of several diseases, such as Noonan syndrome, LEOPARD syndrome as well as myeloid malignancies. Interestingly, both loss-of-function and gain-of-function m...

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Asıl Yazarlar: Wenjie Guo (Yazar), Qiang Xu (Yazar)
Materyal Türü: Kitap
Baskı/Yayın Bilgisi: Elsevier, 2020-11-01T00:00:00Z.
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