A peptide derived from TID1S rescues frataxin deficiency and mitochondrial defects in FRDA cellular models

• 主要な著者: Yi Na Dong (著者), Lucie Vanessa Ngaba (著者), Jacob An (著者), Miniat W. Adeshina (著者), Nathan Warren (著者), Johnathan Wong (著者), David R. Lynch (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2024-03-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Friedreich's ataxia (FRDA), the most common recessive inherited ataxia, results from homozygous guanine-adenine-adenine (GAA) repeat expansions in intron 1 of the FXN gene, which leads to the deficiency of frataxin, a mitochondrial protein essential for iron-sulphur cluster synthesis. The study...