A peptide derived from TID1S rescues frataxin deficiency and mitochondrial defects in FRDA cellular models

• Main Authors: Yi Na Dong (Author), Lucie Vanessa Ngaba (Author), Jacob An (Author), Miniat W. Adeshina (Author), Nathan Warren (Author), Johnathan Wong (Author), David R. Lynch (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Friedreich's ataxia (FRDA), the most common recessive inherited ataxia, results from homozygous guanine-adenine-adenine (GAA) repeat expansions in intron 1 of the FXN gene, which leads to the deficiency of frataxin, a mitochondrial protein essential for iron-sulphur cluster synthesis. The study...