Development of a novel humanized mouse model to study bronchopulmonary dysplasia

• Main Authors: Rob Birkett (Author), Janu Newar (Author), Abhineet M. Sharma (Author), Erika Lin (Author), Lillian Blank (Author), Suchitra Swaminathan (Author), Alexander Misharin (Author), Karen K. Mestan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

RationaleThe role of circulating fetal monocytes in bronchopulmonary dysplasia is not known. We utilized a humanized mouse model that supports human progenitor cell engraftment (MISTRG) to test the hypothesis that prenatal monocyte programming alters early lung development and response to hyperoxia....