Development of a novel humanized mouse model to study bronchopulmonary dysplasia

• Egile Nagusiak: Rob Birkett (Egilea), Janu Newar (Egilea), Abhineet M. Sharma (Egilea), Erika Lin (Egilea), Lillian Blank (Egilea), Suchitra Swaminathan (Egilea), Alexander Misharin (Egilea), Karen K. Mestan (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2023-07-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

RationaleThe role of circulating fetal monocytes in bronchopulmonary dysplasia is not known. We utilized a humanized mouse model that supports human progenitor cell engraftment (MISTRG) to test the hypothesis that prenatal monocyte programming alters early lung development and response to hyperoxia....