Ag120-Mediated Inhibition of ASCT2-Dependent Glutamine Transport has an Anti-Tumor Effect on Colorectal Cancer Cells

• Autors principals: Wei Yu (Autor), Jianwen Huang (Autor), Qichao Dong (Autor), Wenting Li (Autor), Lei Jiang (Autor), Qian Zhang (Autor), Li Sun (Autor), Shengtao Yuan (Autor), Xu He (Autor)
• Format: Llibre
• Publicat: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Metabolic reprogramming is considered to be a hallmark of cancer, and increased glutamine metabolism plays an important role in the progression of many tumors, including colorectal cancer (CRC). Targeting of glutamine uptake via the transporter protein ASCT2/SLC1A5 (solute carrier family 1 member 5)...