Ag120-Mediated Inhibition of ASCT2-Dependent Glutamine Transport has an Anti-Tumor Effect on Colorectal Cancer Cells

• Autori principali: Wei Yu (Autore), Jianwen Huang (Autore), Qichao Dong (Autore), Wenting Li (Autore), Lei Jiang (Autore), Qian Zhang (Autore), Li Sun (Autore), Shengtao Yuan (Autore), Xu He (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Metabolic reprogramming is considered to be a hallmark of cancer, and increased glutamine metabolism plays an important role in the progression of many tumors, including colorectal cancer (CRC). Targeting of glutamine uptake via the transporter protein ASCT2/SLC1A5 (solute carrier family 1 member 5)...