Schistosoma mansoni Sirtuins: characterization and potential as chemotherapeutic targets.

• Päätekijät: Julien Lancelot (Tekijä), Stéphanie Caby (Tekijä), Florence Dubois-Abdesselem (Tekijä), Mathieu Vanderstraete (Tekijä), Jacques Trolet (Tekijä), Guilherme Oliveira (Tekijä), Franz Bracher (Tekijä), Manfred Jung (Tekijä), Raymond J Pierce (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

The chemotherapy of schistosomiasis currently depends on the use of a single drug, praziquantel. In order to develop novel chemotherapeutic agents we are investigating enzymes involved in the epigenetic modification of chromatin. Sirtuins are NAD+ dependent lysine deacetylases that are involved in a...