Schistosoma mansoni Sirtuins: characterization and potential as chemotherapeutic targets.

• Main Authors: Julien Lancelot (Author), Stéphanie Caby (Author), Florence Dubois-Abdesselem (Author), Mathieu Vanderstraete (Author), Jacques Trolet (Author), Guilherme Oliveira (Author), Franz Bracher (Author), Manfred Jung (Author), Raymond J Pierce (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The chemotherapy of schistosomiasis currently depends on the use of a single drug, praziquantel. In order to develop novel chemotherapeutic agents we are investigating enzymes involved in the epigenetic modification of chromatin. Sirtuins are NAD+ dependent lysine deacetylases that are involved in a...