Pharmacological Characterization of FR194921, a New Potent, Selective, and Orally Active Antagonist for Central Adenosine A1 Receptors

• Main Authors: Takuya Maemoto (Author), Miho Tada (Author), Takuma Mihara (Author), Noriko Ueyama (Author), Hideaki Matsuoka (Author), Katsuya Harada (Author), Takayuki Yamaji (Author), Kiyoharu Shirakawa (Author), Satoru Kuroda (Author), Atsushi Akahane (Author), Akinori Iwashita (Author), Nobuya Matsuoka (Author), Seitaro Mutoh (Author)
• Format: Book
• Published: Elsevier, 2004-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Adenosine A1 receptors in the brain are believed to play an important role in brain functioning. We have discovered a novel adenosine A1 receptor antagonist, FR194921 (2-(1-methyl-4-piperidinyl)-6-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-3(2H)-pyridazinone), and characterized the pharmacological activi...