Sample Size Requirements of a Pharmaceutical Material Library: A Case in Predicting Direct Compression Tablet Tensile Strength by Latent Variable Modeling

• Egile Nagusiak: Junjie Cao (Egilea), Haoran Shen (Egilea), Shuying Zhao (Egilea), Xiao Ma (Egilea), Liping Chen (Egilea), Shengyun Dai (Egilea), Bing Xu (Egilea), Yanjiang Qiao (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2024-02-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

The material library is an emerging, new data-driven approach for developing pharmaceutical process models. How many materials or samples should be involved in a particular application scenario is unclear, and the impact of sample size on process modeling is worth discussing. In this work, the direc...