Sample Size Requirements of a Pharmaceutical Material Library: A Case in Predicting Direct Compression Tablet Tensile Strength by Latent Variable Modeling

• Main Authors: Junjie Cao (Author), Haoran Shen (Author), Shuying Zhao (Author), Xiao Ma (Author), Liping Chen (Author), Shengyun Dai (Author), Bing Xu (Author), Yanjiang Qiao (Author)
• Format: Book
• Published: MDPI AG, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The material library is an emerging, new data-driven approach for developing pharmaceutical process models. How many materials or samples should be involved in a particular application scenario is unclear, and the impact of sample size on process modeling is worth discussing. In this work, the direc...