Maternal antibiotic exposure increases total islet number and volume in the neonatal pancreas and reduces HbA1c and insulitis in adult female non‐obese diabetic mice

• Main Authors: Camilla Hartmann Friis Hansen (Author), Martin Haupt‐Jorgensen (Author), Karsten Buschard (Author), Bente Pakkenberg (Author), Lukasz Krych (Author), Axel Kornerup Hansen (Author)
• Format: Book
• Published: Wiley, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Early antibiotic treatment changes susceptibility to disease in rodent models for type 1 diabetes, but the impact that gestational antibiotics may have on pancreatic embryogenesis and β cell function later in life is still unknown. Methods Our aim was to determine whether gestati...