Cytotoxicity of the sesquiterpene lactones neoambrosin and damsin from Ambrosia maritima against multidrug-resistant cancer cells

• Main Authors: Mohamed eSaeed (Author), Stefan eJacob (Author), Louis eSandjo (Author), Yoshikazu eSugimoto (Author), Hassan eKhalid (Author), Till eOpatz (Author), Eckhard eThines (Author), Thomas eEfferth (Author)
• Format: Book
• Published: Frontiers Media S.A., 2015-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Multidrug resistance (MDR) is a prevailing phenomenon leading to chemotherapy treatment failure in cancer patients. In the current study two known cytotoxic pseudoguaianolide sesquiterpene lactones; neombrosin (1) and damsin (2) that circumvent MDR were identified. The two cytotoxic compounds were i...