Combined genetic deletion of GDF15 and FGF21 has modest effects on body weight, hepatic steatosis and insulin resistance in high fat fed mice

• প্রধান লেখক: Satish Patel (লেখক), Afreen Haider (লেখক), Anna Alvarez-Guaita (লেখক), Guillaume Bidault (লেখক), Julia Sarah El-Sayed Moustafa (লেখক), Esther Guiu-Jurado (লেখক), John A. Tadross (লেখক), James Warner (লেখক), James Harrison (লেখক), Samuel Virtue (লেখক), Fabio Scurria (লেখক), Ilona Zvetkova (লেখক), Matthias Blüher (লেখক), Kerrin S. Small (লেখক), Stephen O'Rahilly (লেখক), David B. Savage (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2022-11-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Objectives: Obesity in humans and mice is associated with elevated levels of two hormones responsive to cellular stress, namely GDF15 and FGF21. Over-expression of each of these is associated with weight loss and beneficial metabolic changes but where they are secreted from and what they are require...