Combined genetic deletion of GDF15 and FGF21 has modest effects on body weight, hepatic steatosis and insulin resistance in high fat fed mice

• Main Authors: Satish Patel (Author), Afreen Haider (Author), Anna Alvarez-Guaita (Author), Guillaume Bidault (Author), Julia Sarah El-Sayed Moustafa (Author), Esther Guiu-Jurado (Author), John A. Tadross (Author), James Warner (Author), James Harrison (Author), Samuel Virtue (Author), Fabio Scurria (Author), Ilona Zvetkova (Author), Matthias Blüher (Author), Kerrin S. Small (Author), Stephen O'Rahilly (Author), David B. Savage (Author)
• Format: Book
• Published: Elsevier, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Obesity in humans and mice is associated with elevated levels of two hormones responsive to cellular stress, namely GDF15 and FGF21. Over-expression of each of these is associated with weight loss and beneficial metabolic changes but where they are secreted from and what they are require...