Programmed cell death protein-1 (PD-1) protects liver damage by suppressing IFN-γ expression in T cells in infants and neonatal mice

• Main Authors: Xuangjie Guo (Author), Yiping Xu (Author), Wei Luo (Author), Rongli Fang (Author), Li Cai (Author), Ping Wang (Author), Yuxia Zhang (Author), Zhe Wen (Author), Yanhui Xu (Author)
• Format: Book
• Published: BMC, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Biliary atresia (BA) is a severe cholangiopathy possibly resulting from virus-induced and immune-mediated injury of the biliary system. IFN-γ, secreted from CD4+ Th1 cells and CD8+ cytotoxic T cells, is a major mediator of liver pathology. Programmed death protein-1 (PD-1) signal...