Programmed cell death protein-1 (PD-1) protects liver damage by suppressing IFN-γ expression in T cells in infants and neonatal mice

• Главные авторы: Xuangjie Guo (Автор), Yiping Xu (Автор), Wei Luo (Автор), Rongli Fang (Автор), Li Cai (Автор), Ping Wang (Автор), Yuxia Zhang (Автор), Zhe Wen (Автор), Yanhui Xu (Автор)
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• Опубликовано: BMC, 2021-07-01T00:00:00Z.
• Предметы: article
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Abstract Background Biliary atresia (BA) is a severe cholangiopathy possibly resulting from virus-induced and immune-mediated injury of the biliary system. IFN-γ, secreted from CD4+ Th1 cells and CD8+ cytotoxic T cells, is a major mediator of liver pathology. Programmed death protein-1 (PD-1) signal...