Programmed cell death protein-1 (PD-1) protects liver damage by suppressing IFN-γ expression in T cells in infants and neonatal mice

• Autori principali: Xuangjie Guo (Autore), Yiping Xu (Autore), Wei Luo (Autore), Rongli Fang (Autore), Li Cai (Autore), Ping Wang (Autore), Yuxia Zhang (Autore), Zhe Wen (Autore), Yanhui Xu (Autore)
• Natura: Libro
• Pubblicazione: BMC, 2021-07-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Abstract Background Biliary atresia (BA) is a severe cholangiopathy possibly resulting from virus-induced and immune-mediated injury of the biliary system. IFN-γ, secreted from CD4+ Th1 cells and CD8+ cytotoxic T cells, is a major mediator of liver pathology. Programmed death protein-1 (PD-1) signal...