The effect of amantadine on an ion channel protein from Chikungunya virus.

• Main Authors: Debajit Dey (Author), Shumaila Iqbal Siddiqui (Author), Prabhudutta Mamidi (Author), Sukanya Ghosh (Author), Chandra Shekhar Kumar (Author), Soma Chattopadhyay (Author), Subhendu Ghosh (Author), Manidipa Banerjee (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Viroporins like influenza A virus M2, hepatitis C virus p7, HIV-1 Vpu and picornavirus 2B associate with host membranes, and create hydrophilic corridors, which are critical for viral entry, replication and egress. The 6K proteins from alphaviruses are conjectured to be viroporins, essential during...