Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms

• Main Authors: Melissa D'Ascenzio (Author), Paolo Guglielmi (Author), Simone Carradori (Author), Daniela Secci (Author), Rosalba Florio (Author), Adriano Mollica (Author), Mariangela Ceruso (Author), Atilla Akdemir (Author), Anatoly P. Sobolev (Author), Claudiu T. Supuran (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A large number of novel secondary sulfonamides based on the open saccharin scaffold were synthesized and evaluated as selective inhibitors of four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1). They were obtained by reductive ring opening of the newly synthesized...