Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms

A large number of novel secondary sulfonamides based on the open saccharin scaffold were synthesized and evaluated as selective inhibitors of four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1). They were obtained by reductive ring opening of the newly synthesized...

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Main Authors: Melissa D'Ascenzio (Author), Paolo Guglielmi (Author), Simone Carradori (Author), Daniela Secci (Author), Rosalba Florio (Author), Adriano Mollica (Author), Mariangela Ceruso (Author), Atilla Akdemir (Author), Anatoly P. Sobolev (Author), Claudiu T. Supuran (Author)
Format: Book
Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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