Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms

• Үндсэн зохиолчид: Melissa D'Ascenzio (Зохиогч), Paolo Guglielmi (Зохиогч), Simone Carradori (Зохиогч), Daniela Secci (Зохиогч), Rosalba Florio (Зохиогч), Adriano Mollica (Зохиогч), Mariangela Ceruso (Зохиогч), Atilla Akdemir (Зохиогч), Anatoly P. Sobolev (Зохиогч), Claudiu T. Supuran (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

A large number of novel secondary sulfonamides based on the open saccharin scaffold were synthesized and evaluated as selective inhibitors of four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1). They were obtained by reductive ring opening of the newly synthesized...