Deletion of miR-126a Promotes Hepatic Aging and Inflammation in a Mouse Model of Cholestasis

• Main Authors: Yi Yan (Author), Dan Qin (Author), Bian Hu (Author), Chunjing Zhang (Author), Shenghui Liu (Author), Dongde Wu (Author), Wendong Huang (Author), Xingxu Huang (Author), Liqiang Wang (Author), Xiangmei Chen (Author), Lisheng Zhang (Author)
• Format: Book
• Published: Elsevier, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

MicroRNAs (miRNAs) act as regulators of aging at the tissue or organism level or as regulators of cellular senescence. Targeted deletion of miR-126 in mice causes partial embryonic lethality, but its biological function in the liver is still largely unknown. Here, we deleted miR-126a, using the CRIS...