Deletion of miR-126a Promotes Hepatic Aging and Inflammation in a Mouse Model of Cholestasis

• मुख्य लेखकों: Yi Yan (लेखक), Dan Qin (लेखक), Bian Hu (लेखक), Chunjing Zhang (लेखक), Shenghui Liu (लेखक), Dongde Wu (लेखक), Wendong Huang (लेखक), Xingxu Huang (लेखक), Liqiang Wang (लेखक), Xiangmei Chen (लेखक), Lisheng Zhang (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2019-06-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

MicroRNAs (miRNAs) act as regulators of aging at the tissue or organism level or as regulators of cellular senescence. Targeted deletion of miR-126 in mice causes partial embryonic lethality, but its biological function in the liver is still largely unknown. Here, we deleted miR-126a, using the CRIS...