PGC-1α-Coordinated Hypothalamic Antioxidant Defense Is Linked to SP1-LanCL1 Axis during High-Fat-Diet-Induced Obesity in Male Mice

• Main Authors: Shuai Shi (Author), Jichen Wang (Author), Huan Gong (Author), Xiaohua Huang (Author), Bin Mu (Author), Xiangyu Cheng (Author), Bin Feng (Author), Lanlan Jia (Author), Qihui Luo (Author), Wentao Liu (Author), Zhengli Chen (Author), Chao Huang (Author)
• Format: Book
• Published: MDPI AG, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

High-fat-diet (HFD)-induced obesity parallels hypothalamic inflammation and oxidative stress, but the correlations between them are not well-defined. Here, with mouse models targeting the antioxidant gene <i>LanCL1</i> in the hypothalamus, we demonstrate that impaired hypothalamic antiox...