PGC-1α-Coordinated Hypothalamic Antioxidant Defense Is Linked to SP1-LanCL1 Axis during High-Fat-Diet-Induced Obesity in Male Mice

• मुख्य लेखकों: Shuai Shi (लेखक), Jichen Wang (लेखक), Huan Gong (लेखक), Xiaohua Huang (लेखक), Bin Mu (लेखक), Xiangyu Cheng (लेखक), Bin Feng (लेखक), Lanlan Jia (लेखक), Qihui Luo (लेखक), Wentao Liu (लेखक), Zhengli Chen (लेखक), Chao Huang (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2024-02-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

High-fat-diet (HFD)-induced obesity parallels hypothalamic inflammation and oxidative stress, but the correlations between them are not well-defined. Here, with mouse models targeting the antioxidant gene <i>LanCL1</i> in the hypothalamus, we demonstrate that impaired hypothalamic antiox...