PI3 kinases p110α and PI3K-C2β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets

• 主要な著者: Jelena Kolic (著者), Jocelyn E. Manning Fox (著者), Oleg G. Chepurny (著者), Aliya F. Spigelman (著者), Mourad Ferdaoussi (著者), Frank Schwede (著者), George G. Holz (著者), Patrick E. MacDonald (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2016-07-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Objectives: Phosphatidylinositol-3-OH kinase (PI3K) signalling in the endocrine pancreas contributes to glycaemic control. However, the mechanism by which PI3K modulates insulin secretion from the pancreatic beta cell is poorly understood. Thus, our objective was two-fold; to determine the signallin...