PI3 kinases p110α and PI3K-C2β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets

• Hauptverfasser: Jelena Kolic (Verfasst von), Jocelyn E. Manning Fox (Verfasst von), Oleg G. Chepurny (Verfasst von), Aliya F. Spigelman (Verfasst von), Mourad Ferdaoussi (Verfasst von), Frank Schwede (Verfasst von), George G. Holz (Verfasst von), Patrick E. MacDonald (Verfasst von)
• Format: Buch
• Veröffentlicht: Elsevier, 2016-07-01T00:00:00Z.
• Schlagworte: article
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Objectives: Phosphatidylinositol-3-OH kinase (PI3K) signalling in the endocrine pancreas contributes to glycaemic control. However, the mechanism by which PI3K modulates insulin secretion from the pancreatic beta cell is poorly understood. Thus, our objective was two-fold; to determine the signallin...