Methylene Blue Is a Nonspecific Protein-Protein Interaction Inhibitor with Potential for Repurposing as an Antiviral for COVID-19

• Main Authors: Sung-Ting Chuang (Author), Henrietta Papp (Author), Anett Kuczmog (Author), Rebecca Eells (Author), Jose M. Condor Capcha (Author), Lina A. Shehadeh (Author), Ferenc Jakab (Author), Peter Buchwald (Author)
• Format: Book
• Published: MDPI AG, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We have previously identified methylene blue, a tricyclic phenothiazine dye approved for clinical use for the treatment of methemoglobinemia and for other medical applications as a small-molecule inhibitor of the protein-protein interaction (PPI) between the spike protein of the SARS-CoV-2 coronavir...