U1A is a positive regulator of the expression of heterologous and cellular genes involved in cell proliferation and migration

• Main Authors: Eric Rovira (Author), Beatriz Moreno (Author), Nerea Razquin (Author), Roland Hjerpe (Author), Monika Gonzalez-Lopez (Author), Rosa Barrio (Author), Igor Ruiz de los Mozos (Author), Jernej Ule (Author), Fernando Pastor (Author), Lorea Blazquez (Author), Puri Fortes (Author)
• Format: Book
• Published: Elsevier, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Here, we show that direct recruitment of U1A to target transcripts can increase gene expression. This is a new regulatory role, in addition to previous knowledge showing that U1A decreases the levels of U1A mRNA and other specific targets. In fact, genome-wide, U1A more often increases rather than r...