The cAMP Pathway Amplifies Early MyD88-Dependent and Type I Interferon-Independent LPS-Induced Interleukin-10 Expression in Mouse Macrophages

• Main Authors: Orna Ernst (Author), Yifat Glucksam-Galnoy (Author), Muhammad Athamna (Author), Iris Ben-Dror (Author), Hadar Ben-Arosh (Author), Galit Levy-Rimler (Author), Iain D. C. Fraser (Author), Tsaffrir Zor (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Interleukin-10 (IL-10) is a key anti-inflammatory cytokine, secreted by macrophages and other immune cells to attenuate inflammation. Autocrine type I interferons (IFNs) largely mediate the delayed expression of IL-10 by LPS-stimulated macrophages. We have previously shown that IL-10 is synergistica...