Pre-clinical development of gene modification of haematopoietic stem cells with chimeric antigen receptors for cancer immunotherapy

• मुख्य लेखकों: Sarah M. Larson (लेखक), Laurel C. Truscott (लेखक), Tzu-Ting Chiou (लेखक), Amie Patel (लेखक), Roy Kao (लेखक), Andy Tu (लेखक), Tulika Tyagi (लेखक), Xiang Lu (लेखक), David Elashoff (लेखक), Satiro N. De Oliveira (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Taylor & Francis Group, 2017-05-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Patients with refractory or recurrent B-lineage hematologic malignancies have less than 50% of chance of cure despite intensive therapy and innovative approaches are needed. We hypothesize that gene modification of haematopoietic stem cells (HSC) with an anti-CD19 chimeric antigen receptor (CAR) wil...