Pre-clinical development of gene modification of haematopoietic stem cells with chimeric antigen receptors for cancer immunotherapy

• Hoofdauteurs: Sarah M. Larson (Auteur), Laurel C. Truscott (Auteur), Tzu-Ting Chiou (Auteur), Amie Patel (Auteur), Roy Kao (Auteur), Andy Tu (Auteur), Tulika Tyagi (Auteur), Xiang Lu (Auteur), David Elashoff (Auteur), Satiro N. De Oliveira (Auteur)
• Formaat: Boek
• Gepubliceerd in: Taylor & Francis Group, 2017-05-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Patients with refractory or recurrent B-lineage hematologic malignancies have less than 50% of chance of cure despite intensive therapy and innovative approaches are needed. We hypothesize that gene modification of haematopoietic stem cells (HSC) with an anti-CD19 chimeric antigen receptor (CAR) wil...