Pre-clinical development of gene modification of haematopoietic stem cells with chimeric antigen receptors for cancer immunotherapy

• Autores principales: Sarah M. Larson (Autor), Laurel C. Truscott (Autor), Tzu-Ting Chiou (Autor), Amie Patel (Autor), Roy Kao (Autor), Andy Tu (Autor), Tulika Tyagi (Autor), Xiang Lu (Autor), David Elashoff (Autor), Satiro N. De Oliveira (Autor)
• Formato: Libro
• Publicado: Taylor & Francis Group, 2017-05-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Patients with refractory or recurrent B-lineage hematologic malignancies have less than 50% of chance of cure despite intensive therapy and innovative approaches are needed. We hypothesize that gene modification of haematopoietic stem cells (HSC) with an anti-CD19 chimeric antigen receptor (CAR) wil...