Pre-clinical development of gene modification of haematopoietic stem cells with chimeric antigen receptors for cancer immunotherapy

Pre-clinical development of gene modification of haematopoietic stem cells with chimeric antigen receptors for cancer immunotherapy

Patients with refractory or recurrent B-lineage hematologic malignancies have less than 50% of chance of cure despite intensive therapy and innovative approaches are needed. We hypothesize that gene modification of haematopoietic stem cells (HSC) with an anti-CD19 chimeric antigen receptor (CAR) wil...

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Main Authors: Sarah M. Larson (Author), Laurel C. Truscott (Author), Tzu-Ting Chiou (Author), Amie Patel (Author), Roy Kao (Author), Andy Tu (Author), Tulika Tyagi (Author), Xiang Lu (Author), David Elashoff (Author), Satiro N. De Oliveira (Author)
Format: Book
Published: Taylor & Francis Group, 2017-05-01T00:00:00Z.
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