Pre-clinical development of gene modification of haematopoietic stem cells with chimeric antigen receptors for cancer immunotherapy

• Asıl Yazarlar: Sarah M. Larson (Yazar), Laurel C. Truscott (Yazar), Tzu-Ting Chiou (Yazar), Amie Patel (Yazar), Roy Kao (Yazar), Andy Tu (Yazar), Tulika Tyagi (Yazar), Xiang Lu (Yazar), David Elashoff (Yazar), Satiro N. De Oliveira (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Taylor & Francis Group, 2017-05-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Patients with refractory or recurrent B-lineage hematologic malignancies have less than 50% of chance of cure despite intensive therapy and innovative approaches are needed. We hypothesize that gene modification of haematopoietic stem cells (HSC) with an anti-CD19 chimeric antigen receptor (CAR) wil...