Lubiprostone Improves Distal Segment-Specific Colonic Contractions through TRPC4 Activation Stimulated by EP3 Prostanoid Receptor

• Main Authors: Byeongseok Jeong (Author), Jun Hyung Lee (Author), Jin-A Lee (Author), Seong Jung Kim (Author), Junhyung Lee (Author), Insuk So (Author), Jae Yeoul Jun (Author), Chansik Hong (Author)
• Format: Book
• Published: MDPI AG, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Prokinetic agents are effective in increasing gastrointestinal (GI) contractility and alleviating constipation, often caused by slow intestinal motility. Lubiprostone (LUB), known for activating CLC-2 chloride channels, increases the chloride ion concentration in the GI tract, supporting...