Lubiprostone Improves Distal Segment-Specific Colonic Contractions through TRPC4 Activation Stimulated by EP3 Prostanoid Receptor

• Päätekijät: Byeongseok Jeong (Tekijä), Jun Hyung Lee (Tekijä), Jin-A Lee (Tekijä), Seong Jung Kim (Tekijä), Junhyung Lee (Tekijä), Insuk So (Tekijä), Jae Yeoul Jun (Tekijä), Chansik Hong (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: MDPI AG, 2024-10-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Background: Prokinetic agents are effective in increasing gastrointestinal (GI) contractility and alleviating constipation, often caused by slow intestinal motility. Lubiprostone (LUB), known for activating CLC-2 chloride channels, increases the chloride ion concentration in the GI tract, supporting...