BACE1 Inhibition Increases Susceptibility to Oxidative Stress by Promoting Mitochondrial Damage

• Main Authors: Carolina Francelin (Author), Sayak K. Mitter (Author), Qingwen Qian (Author), Sandeep Kumar Barodia (Author), Colin Ip (Author), Xiaoping Qi (Author), Hongmei Gu (Author), Judith Quigley (Author), Matthew S. Goldberg (Author), Maria B. Grant (Author), Michael E. Boulton (Author)
• Format: Book
• Published: MDPI AG, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACE1 is a key enzyme facilitating the generation of neurotoxic β-amyloid (Aβ) peptide. However, given that BACE1 has multiple substrates we explored the importance of BACE1 in the maintenance of retinal pigment epithelial (RPE) cell homeostasis under oxidative stress. Inhibition of BACE1 reduced mi...