BACE1 Inhibition Increases Susceptibility to Oxidative Stress by Promoting Mitochondrial Damage

• मुख्य लेखकों: Carolina Francelin (लेखक), Sayak K. Mitter (लेखक), Qingwen Qian (लेखक), Sandeep Kumar Barodia (लेखक), Colin Ip (लेखक), Xiaoping Qi (लेखक), Hongmei Gu (लेखक), Judith Quigley (लेखक), Matthew S. Goldberg (लेखक), Maria B. Grant (लेखक), Michael E. Boulton (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2021-09-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

BACE1 is a key enzyme facilitating the generation of neurotoxic β-amyloid (Aβ) peptide. However, given that BACE1 has multiple substrates we explored the importance of BACE1 in the maintenance of retinal pigment epithelial (RPE) cell homeostasis under oxidative stress. Inhibition of BACE1 reduced mi...