Discovery of novel benzohydroxamate-based histone deacetylase 6 (HDAC6) inhibitors with the ability to potentiate anti-PD-L1 immunotherapy in melanoma

• मुख्य लेखकों: Xiaopeng Peng (लेखक), Ziwen Yu (लेखक), Goverdhan Surineni (लेखक), Bulian Deng (लेखक), Meizhu Zhang (लेखक), Chuan Li (लेखक), Zhiqiang Sun (लेखक), Wanyi Pan (लेखक), Yao Liu (लेखक), Shenglan Liu (लेखक), Bin Yu (लेखक), Jianjun Chen (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

In this study, a novel series of histone deacetylases 6 (HDAC6) inhibitors containing polycyclic aromatic rings were discovered and evaluated for their pharmacological activities. The most potent compound 10c exhibited high HDAC6 inhibitory activity (IC50 = 261 nM) and excellent HDAC6 selectivity (S...