Discovery of novel benzohydroxamate-based histone deacetylase 6 (HDAC6) inhibitors with the ability to potentiate anti-PD-L1 immunotherapy in melanoma

• Main Authors: Xiaopeng Peng (Author), Ziwen Yu (Author), Goverdhan Surineni (Author), Bulian Deng (Author), Meizhu Zhang (Author), Chuan Li (Author), Zhiqiang Sun (Author), Wanyi Pan (Author), Yao Liu (Author), Shenglan Liu (Author), Bin Yu (Author), Jianjun Chen (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, a novel series of histone deacetylases 6 (HDAC6) inhibitors containing polycyclic aromatic rings were discovered and evaluated for their pharmacological activities. The most potent compound 10c exhibited high HDAC6 inhibitory activity (IC50 = 261 nM) and excellent HDAC6 selectivity (S...