Reduction of αSYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody

• Główni autorzy: Sahar Roshanbin (Autor), Ulrika Julku (Autor), Mengfei Xiong (Autor), Jonas Eriksson (Autor), Eliezer Masliah (Autor), Greta Hultqvist (Autor), Joakim Bergström (Autor), Martin Ingelsson (Autor), Stina Syvänen (Autor), Dag Sehlin (Autor)
• Format: Książka
• Wydane: MDPI AG, 2022-07-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Immunotherapy targeting aggregated alpha-synuclein (αSYN) is a promising approach for the treatment of Parkinson's disease. However, brain penetration of antibodies is hampered by their large size. Here, RmAbSynO2-scFv8D3, a modified bispecific antibody that targets aggregated αSYN and binds to...