Reduction of αSYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody

• Asıl Yazarlar: Sahar Roshanbin (Yazar), Ulrika Julku (Yazar), Mengfei Xiong (Yazar), Jonas Eriksson (Yazar), Eliezer Masliah (Yazar), Greta Hultqvist (Yazar), Joakim Bergström (Yazar), Martin Ingelsson (Yazar), Stina Syvänen (Yazar), Dag Sehlin (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2022-07-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Immunotherapy targeting aggregated alpha-synuclein (αSYN) is a promising approach for the treatment of Parkinson's disease. However, brain penetration of antibodies is hampered by their large size. Here, RmAbSynO2-scFv8D3, a modified bispecific antibody that targets aggregated αSYN and binds to...