Reduction of αSYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody

• Päätekijät: Sahar Roshanbin (Tekijä), Ulrika Julku (Tekijä), Mengfei Xiong (Tekijä), Jonas Eriksson (Tekijä), Eliezer Masliah (Tekijä), Greta Hultqvist (Tekijä), Joakim Bergström (Tekijä), Martin Ingelsson (Tekijä), Stina Syvänen (Tekijä), Dag Sehlin (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: MDPI AG, 2022-07-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Immunotherapy targeting aggregated alpha-synuclein (αSYN) is a promising approach for the treatment of Parkinson's disease. However, brain penetration of antibodies is hampered by their large size. Here, RmAbSynO2-scFv8D3, a modified bispecific antibody that targets aggregated αSYN and binds to...