Reduction of αSYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody

• मुख्य लेखकों: Sahar Roshanbin (लेखक), Ulrika Julku (लेखक), Mengfei Xiong (लेखक), Jonas Eriksson (लेखक), Eliezer Masliah (लेखक), Greta Hultqvist (लेखक), Joakim Bergström (लेखक), Martin Ingelsson (लेखक), Stina Syvänen (लेखक), Dag Sehlin (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2022-07-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Immunotherapy targeting aggregated alpha-synuclein (αSYN) is a promising approach for the treatment of Parkinson's disease. However, brain penetration of antibodies is hampered by their large size. Here, RmAbSynO2-scFv8D3, a modified bispecific antibody that targets aggregated αSYN and binds to...